Watch Red Bull Salzburg vs Standard Liege Live Streaming
Watch Red Bull Salzburg vs Standard Liege Live StreamingWhile Villa seem to have rediscovered their eye for goal after scoring 10 in their last five games, O'Neill is confident his defence can keep Palace quiet at the opposite end of the pitch.
Villa were undone by two set piece goals when their first meeting ended in a 2-2 draw at Selhurst Park.
But they have the meanest defence in the Premier League - conceding just 21 goals in the top flight so far - and O'Neill added: "A very big plus for us this season has been the inclusion of such players as Stephen Warnock, James Collins and Richard Dunne.
"Dunne is kind of quiet but he is natural leader as he leads by example. For anyone who comes into the side I would think that the confidence the other players are exuding should rub off on them."
Victory for Villa against Palace would take O'Neill closer to unchartered territory in the FA Cup.
