Watch Galatasaray vs Atletico de Madrid Live Streaming
Watch Galatasaray vs Atletico de Madrid Live StreamingVictory for Villa against Palace would take O'Neill closer to unchartered territory in the FA Cup.
The furthest he has ever gone is the quarter-finals and victory against Palace would set-up a place in the last eight against either local rivals West Brom or Reading.
He said: "The quarter-final is the furthest I've been in the FA Cup. I've done it three times as a player at Nottingham Forest, Norwich and at Notts County.
"At County we were beaten by Everton in front of a big, big crowd of about 230! That was 1984 and Everton went on to beat Watford in the final.
"So it would be great to get into the quarter-final this season."
Villa skipper Stiliyan Petrov, whose late goal at Selhurst Park earned O'Neill's side their replay, is battling to shake off a virus in time to figure.
If he is ruled out, it will heap more responsibility on 18-year-old midfielder Fabian Delph.
O'Neill has no doubt that the talented teenager can cope and he added: "I have been very pleased with Fabian Delph. I know he is exceptionally hard on himself. Sometimes that is not a bad thing.
